Naratriptan is an orally active and selective 5-HT1B/1D receptor agonist. Naratriptan is peripherally active and has good oral bioavailability, inducing cranial artery vasoconstriction by activating 5-HT1B/1D receptors (EC50=0.11 µM for dog basilar artery). Naratriptan also inhibits trigeminal nerve-mediated dural neurogenic plasma extravasation and reduces sterile inflammation. Naratriptan is mainly used in the research of acute migraine, targeting cranial vascular and neuroinflammatory mechanisms[1][2][3][4].
Molekulargewicht:
335.46
Reinheit:
98.05
CAS Nummer:
[121679-13-8]
Formel:
C17H25N3O2S
Target-Kategorie:
5-HT Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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