Aminoglutethimide (DL-Aminoglutethimide) is an orally active anticonvulsant with various endocrine-related side effects. Aminoglutethimide blocks multiple steroid hormone synthesis pathways by inhibiting several cytochrome P-450-dependent hydroxylases, such as aromatase, cholesterol side-chain cleavage enzyme, 11-hydroxylase, and 18-hydroxylase, with IC50 values of 0.3, 3.5, 120, and 20 µM, respectively. Aminoglutethimide reduces cortisol levels. Aminoglutethimide can be used in research on Cushings syndrome, breast cancer, and other conditions[1][2][3][4].
Molekulargewicht:
232.28
Reinheit:
98.79
CAS Nummer:
[125-84-8]
Formel:
C13H16N2O2
Target-Kategorie:
Cytochrome P450
Anwendungsbeschreibung:
MCE Product type: Reference compound
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