Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder. Target: PDE4, mACHR Irsogladine treatment (300 and 500 mg/kg/day) resulted in a dose-dependent reduction of angiogenesis in wild-type mice by 21 and 45.3% (P < 0.02, P < 0.001), in tPA-deficient mice by 42.6 and 46% (P < 0.001, P < 0.001), and in uPA-deficient mice by 27.2 and 46% (P < 0.05, p < 0.001), respectively. Irsogladine inhibits bFGF-induced angiogenesis in wild-type, tPA-knockout, and uPA-knockout mice [1]. Irsogladine up-regulates GJIC between PC cells via regulation of the PKA pathway. It also suggests a useful adjuvant of Irsogladine to pancreatic cancer therapy [2]. irsogladine produces the increase of intracellular cAMP content via non-selective inhibition of PDE isozymes, which may be a key mechanism involved in its gastroprotective actions [3].
Molekulargewicht:
256.09
Reinheit:
99.88
CAS Nummer:
[57381-26-7]
Formel:
C9H7Cl2N5
Target-Kategorie:
mAChR,Phosphodiesterase (PDE)
Anwendungsbeschreibung:
MCE Product type: Reference compound
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