Trimebutine-d5 (fumarate), CAS [[2747915-18-8]] Preis auf Anfrage
Artikelnummer:
MCE-HY-B0380S1
Hersteller Artikelnummer:
HY-B0380S1
Alternativnummer:
MCE-HY-B0380S1-5MG,MCE-HY-B0380S1-1MG
Hersteller:
MedchemExpress
Kategorie:
Biochemikalien
Trimebutine-d5 fumarate is deuterium labeled Trimebutine fumarate. Trimebutine fumarate is a multi-target inhibitor and opioid receptor agonist with antimuscarinic activity. Trimebutine fumarate inhibits L-type Ca2+ channels and large-conductance calcium-activated potassium channels (BKCa channels), thereby inhibiting extracellular calcium influx and potassium ion efflux. Trimebutine fumarate also targets Toll-like receptors, inhibits Toll-like receptor 2/4/7/8/9 signals, and inhibits LPS-induced IRAK1 activation, as well as ERK1/2, JNK and NF-kappaB activation, thereby exerting anti-inflammatory effects. Trimebutine fumarate also induces tumor cell apoptosis by inhibiting the AKT/ERK pathway. Trimebutine fumarate also inhibits excessive contraction of smooth muscle and can be used in the study of gastrointestinal disorders such as irritable bowel syndrome (IBS)[1][2][3][4][5][6][7].
