Vardenafil is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5), with an IC50 of 0.7 nM. Vardenafil shows inhibitory towards PDE1, PDE6 with IC50s of 180 nM, and 11 nM, while IC50s are >1000 nM for PDE3 and PDE4[1]. Vardenafil competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels[2]. Vardenafil can be used for the research of erectile dysfunction, hepatitis, diabetes[1]-[6].
Molekulargewicht:
488.60
Reinheit:
99.81
CAS Nummer:
[224785-90-4]
Formel:
C23H32N6O4S
Target-Kategorie:
Endogenous Metabolite,Phosphodiesterase (PDE)
Anwendungsbeschreibung:
MCE Product type: Reference compound
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