(+)-Tetrabenazine ((+)-TBZ, (3R,11bR)-TBZ, (3R,11bR)-Tetrabenazine) is a reversible inhibitor of vesicular monoamine transporter 2 (VMAT-2), inhibits transport by VMAT2 with 10-fold greater potency than transport by VMAT1. target: VMAT-2 In vitro: (+)-Tetrabenazine inhibit the activity of the transporter but appear to interact differently with the protein. [2] (+)-Tetrabenazine inhibits reserpine binding to the transporter, suggesting that the sites may interact in an allosteric manner. [1] In vivo: 0.9% saline (80%) and dimethylsulfoxide (DMSO) (20%). (+)-Tetrabenazine blocks dopamine (DA) storage and depletes striatal DA, (+)-Tetrabenazine was shown to induce tremulous jaw movements (TJMs) in rats and mice. The reference dose for administration is 2.0 mg/kg.[2]
Molekulargewicht:
317.42
Reinheit:
98.72
CAS Nummer:
[1026016-83-0]
Formel:
C19H27NO3
Target-Kategorie:
Monoamine Transporter
Anwendungsbeschreibung:
MCE Product type: Reference compound
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