Ceftiofur sodium is a cell wall synthesis inhibitor that targets bacterial penicillin-binding proteins (PBPs) and has anti-inflammatory effects in endotoxemia. Ceftiofur sodium exerts bactericidal effects by inhibiting the synthesis of bacterial cell wall peptidoglycan, leading to bacterial cell lysis. Ceftiofur sodium also inhibits the activation of NF-kappaB and MAPKs, thereby reducing the secretion of pro-inflammatory cytokines such as TNF-alpha, IL-1beta, and IL-6[1][2][3].
