Hydrastine (Standard) is the analytical standard of Hydrastine (HY-B0927). This product is intended for research and analytical applications. Hydrastine ((-)-beta-Hydrastine, (1R,9S)-beta-Hydrastine) is a selective competitive inhibitor of tyrosine hydroxylase (TH), inhibiting dopamine biosynthesis (IC50=20.7 µM, PC12 cells). Hydrastine also inhibits the organic cation transporter OCT1 (IC50=6.6 µM). Hydrastine may cause neuronal toxicity through mitochondrial dysfunction rather than oxidative stress damage, and can aggravate cell apoptosis when combined with L-DOPA. Hydrastine can be used to study Parkinsons disease-related dopaminergic neuronal damage[1][2].
