Trimipramine is a 5-HT receptor antagonist, with pKi binding values of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively. Trimipramine is also a potent and selective inhibitor targeting human noradrenaline (hNAT), serotonin (hSERT) and organic cation transporters (hOCT1, hOCT2) with IC50 values of 4.99 µM, 2.11 µM, 3.72 µM, 8.00 µM, respectively. Trimipramine has vascular activity and anxiolytic efficacy[1][2][3].
Molekulargewicht:
294.43
CAS Nummer:
[739-71-9]
Formel:
C20H26N2
Target-Kategorie:
5-HT Receptor,Bacterial
Anwendungsbeschreibung:
Reference compound
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