(+)-Magnoflorine (alpha-Magnoflorine) iodide is an orally active aporphine alkaloid with multiple biological activities. (+)-Magnoflorine iodide promotes Parkin/PINK1 -mediated mitochondrial autophagy, inhibits the activation of NLRP3/Caspase-1 pathway, regulates the intestinal microbiota, and exhibits significant anti-inflammatory and immunomodulatory activities. (+)-Magnoflorine iodide inhibits JNK and TLR4/NF-kappaB signaling pathways, activates Sirt1/AMPK pathway, alleviates neuronal oxidative stress and apoptosis. Magnoflorine upregulates miR-410-3p, inhibits HMGB1/NF-kappaB pathway, and has anti-tumor activity. (+)-Magnoflorine iodide also has significant antifungal activity[1][2][3][4][5][6][7].
Molekulargewicht:
469.31
Reinheit:
99.74
CAS Nummer:
[4277-43-4]
Formel:
C20H24INO4
Target-Kategorie:
AMPK,Apoptosis,Autophagy,Caspase,Fungal,JNK,NF-kappaB,NOD-like Receptor (NLR),PINK1/Parkin,Reactive Oxygen Species (ROS),Sirtuin
Anwendungsbeschreibung:
MCE Product type: Natural Products
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