Coptisine is an orally active and brain-penetrant alkaloid found in Coptis chinensis. Coptisine is a reversible, uncompetitive IDO inhibitor with a Ki of 5.8 µM and an IC50 of 6.3 µM. Coptisine suppresses neuroinflammation, reduces Abeta plaque burden and shows neuroprotective activity. Coptisine shows anti-inflammation activity by blocking NF-kappaB, MAPK, and PI3K/Akt activation. Coptisine inhibits cancer cells proliferation, induces DNA damage, G2/M phase cell cycle arrest, apoptosis, ROS production and mitochondrial dysfunction. Coptisine inhibits Rho/ROCK pathway activation, reduces arrhythmia, limits cardiac injury marker release, reduces infarct size, and preserves cardiac function in rat myocardial ischemia/reperfusion models. Coptisine downregulates HMGCR and upregulates LDLR and CYP7A1 to modulate cholesterol metabolism, reduces abnormal serum lipid levels, and promotes fecal bile acid excretion. Coptisine can be used for the research of cancer, hypercholesterolemia, Alzheimers disease, inflammatory disorders and cardiovascular disease[1][2][3][4][5].
Molekulargewicht:
320.32
CAS Nummer:
[3486-66-6]
Formel:
C19H14NO4
Target-Kategorie:
Akt,Apoptosis,DNA/RNA Synthesis,Indoleamine 2,3-Dioxygenase (IDO),LDLR,Mitochondrial Metabolism,NF-kappaB,p38 MAPK,PI3K,Reactive Oxygen Species (ROS),ROCK
Anwendungsbeschreibung:
MCE Product type: Natural Products
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