Liensinine is a bisbenzylisoquinoline alkaloid. By inhibiting the PI3K/AKT and JNK/p38-MAPK signaling pathways, Liensinine suppresses autophagy and apoptosis, clears Abeta, and exerts anti-inflammatory, antioxidant and neuroprotective effects. Liensinine activates AMPK and inhibits the expression of HIF-1alpha and VEGF, thereby suppressing angiogenesis. Liensinine exerts anti-tumor effects through ROS-mediated inhibition of the JAK2/STAT3 signaling pathway. Liensinine can be used for the research of diseases such as Alzheimers disease, hepatocellular carcinoma, osteosarcoma, sepsis-induced organ injury and stroke[1][2][3][4][5].
Molekulargewicht:
610.74
Reinheit:
99.97
CAS Nummer:
[2586-96-1]
Formel:
C37H42N2O6
Target-Kategorie:
Akt,Amyloid-beta,Apoptosis,Autophagy,HIF/HIF Prolyl-Hydroxylase,JAK,JNK,p38 MAPK,PI3K,Reactive Oxygen Species (ROS),STAT,VEGFR
Anwendungsbeschreibung:
MCE Product type: Natural Products
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
