8-O-Acetylharpagide (Standard), CAS [[6926-14-3]] Preis auf Anfrage
Artikelnummer:
MCE-HY-N0757R
Hersteller Artikelnummer:
HY-N0757R
Alternativnummer:
MCE-HY-N0757R-1UNIT
Hersteller:
MedchemExpress
Kategorie:
Biochemikalien
8-O-Acetylharpagide (Standard) is the analytical standard of 8-O-Acetylharpagide. This product is intended for research and analytical applications. 8-O-Acetylharpagide is an iridoid glycoside compound. 8-O-Acetylharpagide exhibits anti-aging activity at low doses and anticancer activity at high doses. 8-O-Acetylharpagide induces late-stage apoptosis and necrosis-like death in cancer cells, and downregulates anti-apoptotic proteins such as Akt, p-Akt and Bcl-2. 8-O-Acetylharpagide is mainly metabolized in rats via demethylation, hydrolysis and glucuronidation, and its active metabolites downregulate the AKT/NF-kappaB/MMP9 signaling axis. 8-O-Acetylharpagide exerts vasoconstrictive effects by activating vascular alpha-adrenoceptor.
