Dihydrosanguinarine is a natural compound isolated from the leaves of Macleaya microcarpa, has antifungal and anticancer activity. IC50 value: Target: in vitro: Dihydrosanguinarine showed much less cytotoxicity than sanguinarine: at the highest concentration tested (20 microM) and 24h exposure, dihydrosanguinarine decreased viability only to 52% [1]. Dihydrosanguinarine showed the highest antifungal activity against B. cinerea Pers, with 95.16% mycelial growth inhibition at 50 µg/ml [2]. dihydrosanguinarine showed the most potent leishmanicidal activities (IC(50) value: 0.014 microg/ml, respectively) [4]. in vivo: Repeated dosing of DHSG for 90 days at up to 500 ppm in the diet (i.e. approximately 58 mg/kg/day) showed no evidence of toxicity in contrast to results published in the literature [3].
Molekulargewicht:
333.34
Reinheit:
99.98
CAS Nummer:
[3606-45-9]
Formel:
C20H15NO4
Target-Kategorie:
Fungal
Anwendungsbeschreibung:
MCE Product type: Natural Products
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