Dihydrochelerythrine is a natural compound isolated from Corydalis yanhusuo, has antifungal activity. IC50 value: Target: in vitro: Dihydrochelerythrine showed the highest antifungal activity against B. cinerea Pers, with 98.32% mycelial growth inhibition at 50 µg/mL. Dihydrochelerythrine inhibited spore germination in vitro in a concentration-dependent manner [1]. Dihydrochelerythrine appeared to be less cytotoxic since the viability of cells exposed to 20 microM dihydrochelerythrine for 24h was reduced only to 53%. A dose-dependent induction of apoptosis and necrosis by chelerythrine and dihydrochelerythrine was confirmed by annexin V/propidium iodide dual staining flow cytometry [2]. Dihydrochelerythrine (4) exhibited strong activity against methicillin-resistant Staphylococcus aureus SK1 and moderate activity against Escherichia coli TISTR 780 with MIC values of 8 and 16 µg/mL, respectively [3].
Molekulargewicht:
349.38
Reinheit:
99.39
CAS Nummer:
[6880-91-7]
Formel:
C21H19NO4
Target-Kategorie:
Fungal
Anwendungsbeschreibung:
MCE Product type: Natural Products
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