(-)-Isocorypalmine (Tetrahydrocolumbamine, (S)-Tetrahydrocolumbamine) is a dopamine receptor ligand and modulator capable of crossing the blood-brain barrier. (-)-Isocorypalmine exhibits receptor selectivity, acting as a partial agonist of dopamine D1 and D5 receptors (coupled via Gs proteins), as well as an antagonist of D2, D3 and D4 receptors (by blocking Gi protein-mediated signaling). (-)-Isocorypalmine shows no significant binding to various non-dopamine receptors, ion channels and transporters. (-)-Isocorypalmine is metabolically stable in vivo, effectively inhibits spontaneous and cocaine-induced hyperlocomotion, sensitization and conditioned place preference in mice, and does not induce addictive place preference when administered alone. (-)-Isocorypalmine can be used in addiction research[1][2].
Molekulargewicht:
341.40
Reinheit:
99.67
CAS Nummer:
[483-34-1]
Formel:
C20H23NO4
Target-Kategorie:
Dopamine Receptor
Anwendungsbeschreibung:
MCE Product type: Natural Products
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