Petasin inhibits adipogenesis in cell 3T3-F442A with an IC50 of 0.95 µM. Petasin inhibits the expression of lipid synthesis factors ACC1, FAS and SCD1 by inhibiting transcription factors PPARgamma and C/EBPalpha, as well as targeting TRPA1 and TRPV1 channels . Petasin inhibits mitochondrial complex I, thereby inhibiting tumor growth and metastasis. Petasin activates AMPK signaling pathway, participating in regulation of glucose and lipid metabolism. Petasin is orally active[1].
Molekulargewicht:
316.43
CAS Nummer:
[26577-85-5]
Formel:
C20H28O3
Target-Kategorie:
AMPK,Mitochondrial Metabolism,PPAR,TRP Channel
Anwendungsbeschreibung:
MCE Product type: Natural Products
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