Catenarin, an anthraquinone compound, inhibits CCR5- and CXCR4-mediated chemotaxis. Catenarin reduces the phosphorylation of mitogen-activated protein kinases (p38 and JNK) and their upstream kinases (MKK6 and MKK7), and calcium mobilization. Catenarin shows anti-inflammatory effect and suppresses leukocyte migration in the diabetes. Catenarin exhibits significant inhibitory effects against Gram-positive bacteria. Catenarin prevents type 1 diabetes (T1D) in nonobese diabetic mice[1][2].
Molekulargewicht:
286.24
CAS Nummer:
[476-46-0]
Formel:
C15H10O6
Target-Kategorie:
Calcium Channel,CCR,CXCR,JNK,p38 MAPK
Anwendungsbeschreibung:
MCE Product type: Natural Products
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