Nocarnickelamide B (Compound 2) is a linear peptide and ROCK1/2 inhibitor. Nocarnickelamide B exhibits dual inhibitory activity against ROCK1 and ROCK2 with IC50s of 14.9 µM and 21.9 µM, respectively. Nocarnickelamide B binds to the ATP-binding site. Nocarnickelamide B inhibits the activation of ROCK-regulated cytoskeletal contraction markers such as the myosin light chain. Nocarnickelamide B is potential for glaucoma reasearch[1].
Molekulargewicht:
618.68
Formel:
C29H42N6O9
Target-Kategorie:
Myosin,ROCK
Anwendungsbeschreibung:
MCE Product type: Natural Products
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