Ginnalin A (Acertannin) is a Nrf2 activator. Ginnalin A shows antiproliferative activity against HCT116, SW480 and SW620 cells with IC50 values of 24.8, 22.0, and 39.7 µM, respectively. Ginnalin A can induce cancer cells S phase arrest. Ginnalin A can activate the p62-Keap1-Nrf2 signaling pathway, significantly upregulate the mRNA and protein expression of Nrf2, HO-1, and NQO1, and promote the transport of Nrf2 from the cytoplasm to the nucleus. Ginnalin A can be used for the research of colon cancer[1].
Molekulargewicht:
468.37
CAS Nummer:
[76746-56-0]
Formel:
C20H20O13
Target-Kategorie:
Heme Oxygenase (HO),Keap1-Nrf2,p62
Anwendungsbeschreibung:
MCE Product type: Natural Products
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