4-O-Methylbavachalcone is an orally active prenylated flavonoid that inhibits the activity of SARS-CoV papain-like protease (PLpro), with an IC50 of 10.1 µM and a Ki of 4.6 µM. 4-O-Methylbavachalcone inhibits poly (ADP-ribose) polymerase-mediated cell death (parthanatos), reduces cerebral infarct volume, binds to the orthosteric site of SUCNR1, blocks the interaction between succinate and SUCNR1, inhibits SUCNR1 activity, blocks the nuclear translocation of NFATc4, suppresses the activation of the ERK1/2 signaling pathway, inhibits cardiomyocyte hypertrophy and restores the expression of alpha-actinin. 4-O-Methylbavachalcone can be used in studies related to ischemic stroke, SARS-CoV and cardiomyocyte hypertrophy[1][2][3].
Molekulargewicht:
338.40
Reinheit:
99.64
CAS Nummer:
[20784-60-5]
Formel:
C21H22O4
Target-Kategorie:
ERK,SARS-CoV,Succinate Receptor 1,Virus Protease
Anwendungsbeschreibung:
MCE Product type: Natural Products
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