Demethylwedelolactone is a naturally occurring coumestan found in Eclipta alba andWedelia calendulacea. Demethylwedelolactone inhibits trypsin with an IC50 of 3.0 µg/mL. Demethylwedelolactone blocks MEK/ERK and NF-kB signaling pathways via inhibited phosphorylation of ERK and IkB-alpha. Demethylwedelolactone reduces MMP-2 and MMP-9 activity and expression, suppresses breast cancer cell motility, invasion, and tumor metastasis. Demethylwedelolactone inhibits mast cell degranulation, and LPS (HY-D1056)-stimulated NO, TNF-alpha, IL-1beta, and IL-6 production. Demethylwedelolactone improves liver function and reduces hepatic fat accumulation. Demethylwedelolactone can be used for the research of cancer, inflammation and metabolic disease[1][2][3][4].
Molekulargewicht:
300.22
Reinheit:
99.89
CAS Nummer:
[6468-55-9]
Formel:
C15H8O7
Target-Kategorie:
Ser/Thr Protease
Anwendungsbeschreibung:
MCE Product type: Natural Products
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
