Geissoschizine methyl ether is an orally active, blood-brain barrier permeable alkaloid, and a partial agonist of the 5-HT1A receptor. It can be isolated from Uncaria hook. Geissoschizine methyl ether potently inhibits the binding of [3H]8-OH-DPAT to the 5-HT1A receptor in a concentration-dependent manner, with an IC50 of 0.904 µM. It ameliorates isolation-induced increased aggression and reduced sociability in mice. Geissoschizine methyl ether promotes oligodendrocyte differentiation and remyelination in the medial prefrontal cortex of adult mice[1][2][3].
Molekulargewicht:
366.45
Reinheit:
99.97
CAS Nummer:
[60314-89-8]
Formel:
C22H26N2O3
Target-Kategorie:
5-HT Receptor
Anwendungsbeschreibung:
MCE Product type: Natural Products
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