Oroxylin A-7-O-glucuronide (oroxyloside) is an orally active flavonoid glucuronide and metabolite of Oroxylin A (HY-N0560). Oroxylin A-7-O-glucuronide can be extracted from the dried root of Scutellaria baicalensis. Oroxylin A-7-O-glucuronide exhibits prolyl oligopeptidase inhibitory activity. Oroxylin A-7-O-glucuronide inhibits the JNK pathway, upregulates PPARgamma, and inhibits NF-kappaB p65 nuclear translocation. Oroxylin A-7-O-glucuronide reduces cytokine (IL-1beta, IL-6) production. Oroxylin A-7-O-glucuronide exhibits anti-angiogenic, anti-tumor (glioma, liver cancer), anti-inflammatory, and hepatoprotective activities[1][2][3][4][5][6].
Molekulargewicht:
460.39
Reinheit:
99.83
CAS Nummer:
[36948-76-2]
Formel:
C22H20O11
Target-Kategorie:
Drug Metabolite,Interleukin Related,JNK,NF-kappaB,PPAR,Prolyl Endopeptidase (PREP)
Anwendungsbeschreibung:
Natural Products
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