7,4-Dihydroxyflavone (7,4-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC50=0.28 µM). 7,4-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)-paradoxical adverse effects on eotaxin production[1]. 7,4-Dihydroxyflavone (7,4-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-kappaB, STAT6 and HDAC2.7,4-Dihydroxyflavone (7,4-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM[1].
Molekulargewicht:
254.24
CAS Nummer:
[2196-14-7]
Formel:
C15H10O4
Target-Kategorie:
CCR,COX,NF-kappaB,Reference Standards
Anwendungsbeschreibung:
MCE Product type: Reference Standards
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