3',4',7-Trihydroxyflavone is an orally active inhibitor of OXA-48 (IC50 = 1.89 µM) and COX-1 (IC50 = 36.37 µM). 3',4',7-Trihydroxyflavone exhibits antioxidant and anti-inflammatory properties, inhibiting the release of inflammatory cytokines such as IL-6, IL-8, and TNF-alpha. 3',4',7-Trihydroxyflavone inhibits H2O2-induced neuronal apoptosis and ROS accumulation, and exerts anti-neuroinflammatory effects by suppressing the JNK-STAT1 pathway. 3',4',7-Trihydroxyflavone exhibits antimicrobial and antibiotic-modifying activities against multidrug-resistant Gram-negative enteric bacteria. 3',4',7-Trihydroxyflavone inhibits RANKL-induced osteoclast formation via NFATc1. 3',4',7-Trihydroxyflavone activates the CREB-BDNF axis and restores scopolamine (HY-N0296)-induced memory deficits in mice[1][2][3][4][5][6][7][8][9].
Molekulargewicht:
270.24
Reinheit:
98
CAS Nummer:
[2150-11-0]
Formel:
C15H10O5
Target-Kategorie:
Akt,Apoptosis,Bacterial,Bcl-2 Family,Beta-lactamase,Caspase,COX,ERK,Interleukin Related,JNK,Lactate Dehydrogenase,NO Synthase,Nuclear Factor of activated T Cells (NFAT),p38 MAPK,Reactive Oxygen Species (ROS),SOD,STAT
Anwendungsbeschreibung:
MCE Product type: Natural Products
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