Arjunolic acid is an orally active, multifunctional bioactive compound. Arjunolic acid exhibits free radical scavenging activity, as well as fungal and bacterial activities. Arjunolic acid induces apoptosis (Apoptosis) in various cancer cells. Arjunolic acid protects hepatocytes against induced oxidative stress and apoptosis by reducing reactive oxygen species and inhibiting NF-kappaB activation. Arjunolic acid regulates pancreatic dysfunction in type 2 diabetic rats by blocking the activation of the TLR-4/MyD88 and canonical Wnt pathways. Arjunolic acid inhibits neuroinflammation and ameliorates depressive behaviors via the SIRT1/AMPK/Notch1 signaling pathway in microglia. Arjunolic acid improves Crohns disease-like colitis by restoring gut microbiota composition and inhibiting TLR4 signaling. Arjunolic acid suppresses osteosarcoma progression by inhibiting Wnt3a-mediated M2 polarization of macrophages. Arjunolic acid ameliorates diabetic retinopathy via the autophagy pathway regulated by AMPK/mTOR/HO-1. Arjunolic acid is applicable to research related to type 2 diabetes, organ toxicity, depression, Crohns disease, osteosarcoma, diabetic retinopathy, and testicular dysfunction[1][2][3][4][5][6][7].
Molekulargewicht:
488.70
Reinheit:
98.83
CAS Nummer:
[465-00-9]
Formel:
C30H48O5
Target-Kategorie:
AMPK,Apoptosis,Bacterial,Fungal,mTOR,MyD88,NF-kappaB,Notch,Reactive Oxygen Species (ROS),Sirtuin,SOD,Toll-like Receptor (TLR),Wnt
Anwendungsbeschreibung:
MCE Product type: Natural Products
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