Deapi-platycodin D3 is a PTP1B inhibitor. Deapi-platycodin D3 directly binds to PTP1B, activates the PKM2/AMPK pathway, and maintains cartilage homeostasis. Deapi-platycodin D3 promotes the production of extracellular matrix components. Deapi-platycodin D3 exerts anti-inflammatory effects in LPS (HY-D1056)-stimulated macrophages. Deapi-platycodin D3 delays disease progression in a mouse model of trauma-induced osteoarthritis. Deapi-platycodin D3 can be used for research related to osteoarthritis[1].