Cytochalasin D (Zygosporin A) is a potent actin polymerization inhibitor, could be derived from fungus. Cytochalasin D has cell-permeable activity. Cytochalasin D inhibits the G-actin-cofilin interaction by binding to G-actin. Cytochalasin D also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of Yap[1][2][3][4].
Molekulargewicht:
507.62
Reinheit:
99.76
CAS Nummer:
[22144-77-0]
Formel:
C30H37NO6
Target-Kategorie:
Antibiotic,Arp2/3 Complex,YAP
Anwendungsbeschreibung:
MCE Product type: Natural Products
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