Destruxin B, isolated from entomopathogenic fungus Metarhizium anisopliae, is one of the cyclodepsipeptides with insecticidal and anticancer activities. Destruxin B induces apoptosis via a Bcl-2 Family-dependent mitochondrial pathway in human nonsmall cell lung cancer cells[1]. Destruxin B significantly activates caspase-3 and reduces tumor cell proliferation through caspase-mediated apoptosis, not only in vitro but also in vivo[2].
Molekulargewicht:
621.81
Reinheit:
99.86
CAS Nummer:
[2503-26-6]
Formel:
C32H55N5O7
Target-Kategorie:
Apoptosis,Bcl-2 Family,Caspase
Anwendungsbeschreibung:
MCE Product type: Natural Products
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