Borrelidin (Treponemycin) is a bacterial and eukaryal threonyl-tRNA synthetase inhibitor which is a nitrile-containing macrolide antibiotic isolated from Streptomyces rochei[1]. Borrelidin is an inhibitor of Cdc28/Cln2 of the budding yeast, with an IC50 of 24 µM[2]. Borrelidin is a potent angiogenesis inhibitor, with an IC50 of 0.8 nM. Borrelidin induces apoptosis in the tube-forming cells[3]. Borrelidin has strong antimalarial activities, with IC50s of 1.9 nM and 1.8 nM against K1 and FCR3 strains of Plasmodium falciparum, respectively[4].
Molekulargewicht:
489.64
Reinheit:
99.80
CAS Nummer:
[7184-60-3]
Formel:
C28H43NO6
Target-Kategorie:
Antibiotic,Apoptosis,CDK,Parasite
Anwendungsbeschreibung:
MCE Product type: Natural Products
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