Okadaic acid sodium, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid (sodium) has a significantly higher affinity for PP2A (IC50=0.1-0.3 nM), and inhibits PP1 (IC50=15-50 nM), PP3 (IC50=3.7-4 nM), PP4 (IC50=0.1 nM), PP5 (IC50=3.5 nM), but does not inhibit PP2C. Okadaic acid sodium increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. Okadaic acid sodium induces tau phosphorylation[1][2].
Molekulargewicht:
826.98
Reinheit:
99.90
CAS Nummer:
[209266-80-8]
Formel:
C44H67NaO13
Target-Kategorie:
Apoptosis,Phosphatase
Anwendungsbeschreibung:
MCE Product type: Reference compound
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