ent-(+)-verticilide is a potent and selective inhibitor of cardiac ryanodine receptor (RyR2) calcium release channels with antiarrhythmic activity. ent-(+)-verticilide inhibits RyR2-mediated diastolic Ca2+ leak and exhibits higher potency and a distinct mechanism of action compared with theDantrolene and Tetracaine. ent-(+)-verticilide is a useful tool to investigate the therapeutic potential of targeting RyR2 hyperactivity in heart and brain pathologies[1].
Molekulargewicht:
853.09
Reinheit:
99.91
CAS Nummer:
[2056011-05-1]
Formel:
C44H76N4O12
Target-Kategorie:
Calcium Channel
Anwendungsbeschreibung:
Peptides
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