13-Hydroxyisobakuchiol (Delta3,2-Hydroxylbakuchiol), an analog of Bakuchiol (HY-N0235) that can be isolated from Psoralea corylifolia (L.), is a potent selective monoamine transporter inhibitor. 13-Hydroxyisobakuchiol is more selective for the dopamine transporter (DAT) (IC50 = 0.58 µM) and norepinephrine transporter (NET) (IC50 = 0.69 µM) than for the serotonin transporter (SERT) (IC50 = 312.02 µM). 13-Hydroxyisobakuchiol increases the activity of intact mice and improves the decreased activity of reserpinized mice in vivo. 13-Hydroxyisobakuchiol can be used for the research of disorders such as Parkinsons disease and depression[1].
Molekulargewicht:
272.38
CAS Nummer:
[178765-49-6]
Formel:
C18H24O2
Target-Kategorie:
Dopamine Transporter,Monoamine Transporter
Anwendungsbeschreibung:
MCE Product type: Natural Products
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
