Emestrin is a mycotoxin originally isolated from E. striata that has antimicrobial, immunomodulatory, and cytotoxic activities. It is active against the fungi C. albicans and C. neoformans, as well as the bacteria E. coli, S. aureus, and methicillin-resistant S. aureus (MRSA, IC50s=3.94, 0.6, 2.21, 4.55, and 2.21 µg/mL, respectively).2 Emestrin is a chemokine (C-C motif) receptor 2 (CCR2) antagonist (IC50=5.4 µM in a radioligand binding assay using isolated human monocytes).3 Emestrin (0.1 µg/mL) induces apoptosis in HL-60 cells. It induces heart, thymus, and liver tissue necrosis in mice when administered at doses ranging from 18 to 30 mg/kg.
Molekulargewicht:
598.60
CAS Nummer:
[97816-62-1]
Formel:
C27H22N2O10S2
Target-Kategorie:
Bacterial
Anwendungsbeschreibung:
MCE Product type: Natural Products
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