6-Methoxyflavanone (6-MeOF) is a flavonoid compound that can cross the blood-brain barrier. 6-Methoxyflavanone is a positive allosteric modulator of GABAA receptors. 6-Methoxyflavanone exhibits positive allosteric regulatory effects on human recombinant alpha1beta2gamma2L and alpha2beta2gamma2L GABAA receptors, and is relatively inactive on the alpha1beta2 GABAA receptor. 6-Methoxyflavanone showes inhibitory behavior towards the activation of bitter receptor hTAS2R39 and hTAS2R14, demonstrating a reversible and non-overcome antagonistic effect. 6-Methoxyflavanone has the effects of anti-anxiety, analgesia and relief of neuropathic pain[1][2][3][4].
Molekulargewicht:
254.28
Reinheit:
98.95
CAS Nummer:
[3034-04-6]
Formel:
C16H14O3
Target-Kategorie:
GABA Receptor,Taste Receptor
Anwendungsbeschreibung:
MCE Product type: Natural Products
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