Human immunoglobulin E (Human IgE) is a key immunoglobulin and receptor-binding protein. Human immunoglobulin E reduces extracellular pH by enhancing the activity of Na+/H+ exchanger NHE1, and forms complexes with FcepsilonR1, TLR4 to initiate signal transduction pathways, inducing the expression of inflammatory cytokines/chemokines, as well as pro-inflammatory, pro-apoptotic (apoptosis) and pro-atherosclerotic effects along with cell apoptosis. Human immunoglobulin E enhances the activities of pro-atherosclerotic cathepsin S and K in macrophages, and synergizes with LPS or oxidized LDL to promote IL-6 secretion by macrophages. Human immunoglobulin E also upregulates the expression of FcepsilonRI on the surface of mast cells, and synergizes with IL-4 to strengthen the expression of this protein, thereby increasing the sensitivity and intensity of the release of mediators such as histamine, prostaglandin D2 and leukotriene C4 from mast cells. Human immunoglobulin E mainly localizes to macrophage-rich areas, smooth muscle cell fibrous caps and endothelial cells in human atherosclerotic lesions. Human immunoglobulin E can be used for research on coronary heart disease, atherosclerosis, acute myocardial infarction, unstable angina pectoris, stable angina pectoris and allergic diseases[1][2].
Reinheit:
95
Target-Kategorie:
Fc Receptor (FcR),Na+/H+ Exchanger (NHE),Toll-like Receptor (TLR)
Anwendungsbeschreibung:
MCE Product type: Biochemical Assay Reagents
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