Tat-NR2B9c TFA (Tat-NR2Bct TFA) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c TFA disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC50 values of 0.5 µM and 8 µM, respectively. Tat-NR2B9c TFA also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy[1].
Molekulargewicht:
2632.90
Reinheit:
99.66
CAS Nummer:
[1834571-04-8]
Formel:
C105H188N42O30.C2HF3O2
Target-Kategorie:
iGluR,NO Synthase
Anwendungsbeschreibung:
Peptides
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