PGD97 is a selective cyclic peptide inhibitor against CAL/CFTR interactions, with a KD value of 6 nM towards the CAL PDZ domain for its desulfide cyclized form. PGD97 (desulfide cyclized form) has selectivity 130-fold compared to NHERF1/2 PDZ domains. PGD97 is capable of stabilizing F508del-CFTR at the cell membrane and improving CFTR function required for proper fluid homeostasis in tne lung. PGD97 can be used for the research of cystic fibrosis[1].
Molekulargewicht:
1643.01
CAS Nummer:
[2717490-36-1]
Formel:
C74H111N23O14S3
Target-Kategorie:
CFTR,Chloride Channel
Anwendungsbeschreibung:
MCE Product type: Peptides
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