omega-Agatoxin IVA TFA is a potent, selective P/Q type Ca2+ (Cav2.1) channel blocker with IC50s of 2 nM and 90 nM for P-type and Q-type Ca2+ channels, respectively. omega-Agatoxin IVA TFA (IC50, 30-225 nM) inhibits glutamate exocytosis and calcium influx elicited by high potassium. omega-Agatoxin IVA TFA also blocks the high potassium-induced release of serotonin and norepinephrine. omega-Agatoxin IVA TFA has no effect on L-type or N-type calcium channels[1][2].
Molekulargewicht:
5316.27
Reinheit:
99.10
Formel:
C217H360N68O60S10.C2HF3O2
Target-Kategorie:
Calcium Channel
Anwendungsbeschreibung:
Peptides
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