Oncocin is an antibacterial peptide. It belongs to proline-rich antimicrobial peptides (PrAMPs). Oncocin works against Gram-negative bacteria. It has MIC values of 0.125-8 µg/mL for 34 strains and clinical isolates of Enterobacteriaceae and nonfermenters. Oncocin binds to the substrate-binding domain of the chaperone DnaK. The binding has dissociation constants in the micromolar range. This binding causes protein misfolding and aggregation and the bacteria death[1][2].
Molekulargewicht:
2389.81
CAS Nummer:
[1235497-90-1]
Formel:
C109H177N37O24
Target-Kategorie:
Bacterial
Anwendungsbeschreibung:
Peptides
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