RP-182 acetate is a synthetic immunomodulatory peptide that exerts anti-tumor effects by targeting the mannose receptor CD206 (Kd = 8 µM) on the surface of tumor-associated macrophages (TAMs). RP-182 acetate induces a conformational switch of the CD206 receptor, which activates NF-kappaB signaling and phagocytosis in CD206high TAMs. RP-182 acetate has dual function: activation of canonical NF-kappaB signaling, triggering TNFalpha secretion and autocrine activation of the TNF receptor 1 (TNFR1), leading to activation of caspase 8, apoptosis, and cell death. RP-182 acetate is used in pancreatic cancer and melanoma research[1][2].
Molekulargewicht:
1374.68 (free base)
Reinheit:
98.78
Formel:
C69H103N19O11xC2H4O2
Target-Kategorie:
Apoptosis,Caspase,NF-kappaB,TNF Receptor
Anwendungsbeschreibung:
MCE Product type: Peptides
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
