WKYMVM-NH2 is a hexapeptide that activates neutrophils and myeloid cells via the FPRL1 and FPRL2 receptors. It exhibits EC50 values of 2 nM and 80 nM in HL-60-FPRL1 and HL-60-FPRL2 cells, respectively. In HL-60 cells stably expressing FPRL2, WKYMVM-NH2 induces chemotaxis, with optimal migration observed at concentrations ranging from 10 to 50 nM. It also stimulates superoxide production in neutrophils, with an EC50 of 75 nM. WKYMVM-NH2 is a useful tool for research in the field of inflammatory diseases[1].
Molekulargewicht:
856.11
CAS Nummer:
[187986-11-4]
Formel:
C41H61N9O7S2
Target-Kategorie:
Formyl Peptide Receptor (FPR)
Anwendungsbeschreibung:
MCE Product type: Peptides
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