NAB815 is a specific inhibitor of the Stx2a (Kd = 0.01 µM)/TLR4 interaction. NAB815 inhibits the neutrophil/Stx2a interaction (IC50 = 0.057 µg/mL). NAB815 inhibits the formation of Stx2-containing extracellular vesicles (EVs) produced by leukocytes and platelets and reduces their toxic effects in cellular (Vero cells) and animal models (CD-1 mice). NAB815 reduces bacterial loads in the kidneys, urine, and bladders of Escherichia coli-infected mice. NAB815 is useful in the study of hemolytic uremic syndrome (HUS)[1][2].
Molekulargewicht:
1175.42
CAS Nummer:
[1969250-99-4]
Formel:
C55H94N14O14
Target-Kategorie:
Bacterial,Toll-like Receptor (TLR)
Anwendungsbeschreibung:
MCE Product type: Peptides
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
