CCKBR agonist-1 (Compound 3r1) is a Gq-protein-preferring cholecystokinin B receptor (CCKBR) agonist with an EC50 of 35 pM. CCKBR agonist-1 significantly increases the survival rate of neurons, with an EC50 of 37 pM. CCKBR agonist-1 can improve the cognitive decline in mice by upregulating alpha-secretase (ADAM10) and calcium signaling molecule PLCB4, reduce the number of amyloid beta (Abeta) plaques, and promote long-term potentiation (LTP). CCKBR agonist-1 can be used for the study of Alzheimers disease[1].
Molekulargewicht:
699.59
Reinheit:
98.48
CAS Nummer:
[2923120-30-1]
Formel:
C32H39BrN6O7
Target-Kategorie:
Amyloid-beta,Cholecystokinin Receptor,MMP
Anwendungsbeschreibung:
MCE Product type: Peptides
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