alpha-Casein (90-95) TFA is a partial agonist of opioid receptors and a copper ion ligand, with opioid activity. alpha-Casein (90-95) TFA inhibits the secretion of beta-hexosaminidase by rat peritoneal mast cells (PMC) with IC50= 0.1 µM. alpha-Casein (90-95) TFA inhibits the proliferation of prostate cancer cells LNCaP, DU145, and PC3 with IC50 of 0.94 nM, 137 nM, and 6.92 nM, respectively. alpha-Casein (90-95) TFA activates Gi-like proteins through a membrane-assisted, receptor-independent pathway, or reversibly binds to opioid receptors, inducing intracellular calcium release and conformational changes, and exerts the activity of promoting mast cell secretion and inhibiting tumor cell proliferation. alpha-Casein (90-95) TFA can be used in the study of the mechanisms of allergic diseases and prostate cancer[1][2][3].
Molekulargewicht:
897.94
Reinheit:
99.58
Formel:
C40H58F3N9O11
Target-Kategorie:
Biochemical Assay Reagents,Opioid Receptor
Anwendungsbeschreibung:
MCE Product type: Peptides
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
