HXR9 is a cell-permeable peptide and a competitive antagonist of HOX/PBX interaction. HXR9 antagonizes the interaction between HOX and a second transcrip-tion factor (PBX), which binds to HOX proteins in paralogue groups1 to 8. HXR9 selectively decreases cell proliferation and promotes apoptosis in cells with a high level of expression of the HOXA/PBX3 genes, such as MLL-rearranged leukemic cells[1][2][3].
Molekulargewicht:
2718.21
CAS Nummer:
[917953-08-3]
Formel:
C119H193N53O20S
Target-Kategorie:
Apoptosis
Anwendungsbeschreibung:
MCE Product type: Peptides
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