Hippuryl-His-Leu-OH, CAS [[31373-65-6]] Preis auf Anfrage
Artikelnummer:
MCE-HY-P4551
Hersteller Artikelnummer:
HY-P4551
Alternativnummer:
MCE-HY-P4551-1UNIT
Hersteller:
MedchemExpress
Kategorie:
Proteine/Peptide
Alternative Synonym:
N-Benzoyl-Gly-His-Leu
Hippuryl-His-Leu-OH (N-Benzoyl-Gly-His-Leu) is a specific substrate for angiotensin-converting enzyme (ACE I) and a molecular tool used for ACE activity detection in in vitro experiments. Hippuryl-His-Leu-OH is hydrolyzed by ACE through competitive binding. Under ACE catalysis, Hippuryl-His-Leu-OH undergoes hydrolysis to produce hippuric acid (HA). The amount of HA produced can be used to quantitatively assess ACE activity or screen for ACE inhibitors. The released His-Leu can also react with o-phthalaldehyde or Fluorescamine (HY-D0715) for fluorescence detection. Hippuryl-His-Leu-OH can be applied to the in vitro screening of ACE inhibitors for hypertension and cardiovascular diseases, and is also used in the study of ACE activity changes in physiological and pathological processes such as renal compensatory hypertrophy[1][2][3].
