PICALM Protein, Human (HEK293, His) plays a critical role in recruiting clathrin and adapter protein complex 2 (AP2) to the cell membrane during coated pit formation and clathrin-vesicle assembly effect. It regulates the size of the clathrin cage and determines membrane recycling. PICALM Protein, Human (HEK293, His) is the recombinant human-derived PICALM protein, expressed by HEK293 , with C-10*His labeled tag.