IL-4R alpha is a subunit alpha shared by IL-4 and IL-13 receptors, found in leukocytes originally. IL-4R alpha couples to the JAK1/2/3-STAT6 pathway and involves in promoting Th2 differentiation. IL-4R alpha/CD124, exerts IL-4 binding function and results the phosphorylation of C-terminal tyrosine residues. IL-4R alpha/CD124, Mouse has an immunoreceptor tyrosine inhibitor motif (ITIM) (707-712 a.a), which can bind to the SH2 domain of some phosphatases by phosphorylating ITIM. IL-4R alpha/CD124 Protein, Mouse (HEK293, Fc) has a transmembrane domain (234-257 a.a). IL-4R alpha/CD124 Protein, Mouse is produced in HEK293 cells, including a Fibronectin typr III domain and a C-terminal hFC-tag.
Molekulargewicht:
65-80 kDa
Reinheit:
95
Formel:
16190(Gene_ID)P16382-1 (I26-R233)(Accession)
Anwendungsbeschreibung:
MCE Product type: Recombinant Proteins
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